Let’s see if Vitamin B3 can prevent skin cancer. Skin cancer, a condition where abnormal cell growth occurs in the skin, is a prevalent concern affecting a substantial number of people each year. Globally, millions grapple with the consequences of this condition. How deadly is it? Let’s look into the potential preventative measures, particularly the promising role of Vitamin B3.

Research suggests that Vitamin B3, in the form of nicotinamide, plays a crucial role in dermatology. Nicotinamide, a water-soluble B3 derivative, has multifaceted functions in medicine. Its effectiveness in preventing skin cancer and photoaging is a subject of growing interest.

Ultraviolet radiation (UV) poses a significant risk in skin cancer development. Nicotinamide steps in by preventing UV from reducing ATP levels and inhibiting glycolysis, thwarting the UV-induced energy crisis. This not only enhances DNA repair but also reduces UV-induced suppression of immunity, offering a protective shield against the harmful effects of sun exposure.

Clinical trials employing a randomized controlled approach have reinforced the positive impact of nicotinamide. Results indicate a reduction in transepidermal water loss and the development of new non-melanoma skin cancers in high-risk individuals. This promising evidence underscores the potential of Vitamin B3 as a preventive measure.

While embracing nicotinamide as a supplement may offer a level of protection, it’s crucial to acknowledge that it’s not a substitute for regular skin cancer checks conducted by a medical professional. Vigilance and routine screenings remain paramount in early detection and management.

In conclusion, Vitamin B3, particularly in the form of nicotinamide, emerges as a promising avenue in the prevention of skin cancer. Its multifaceted actions, from DNA repair enhancement to immunity support, mark it as a valuable player in dermatological health. However, it should complement rather than replace regular medical check-ups for a comprehensive approach to skin cancer prevention.


Snaidr VA, Damian DL, Halliday GM. Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Exp Dermatol. 2019 Feb;28.

Chen AC, Damian DL. Nicotinamide and the skin. Australas J Dermatol. 2014 Aug;55(3):169-75. doi: 10.1111/ajd.12163. Epub 2014 Mar 17. PMID: 24635573.